Lose up to 22%
Our most effective option for maximum weight loss results — with full lifestyle support included.
Lose up to 15%
A proven GLP-1 treatment with full lifestyle support included.
Everything you need to lose weight, all in one app.
Lose up to 22%
Our most effective option for maximum weight loss results — with full lifestyle support included.
Lose up to 15%
A proven GLP-1 treatment with full lifestyle support included.
Everything you need to lose weight, all in one app.
1️⃣ Weight regain after discontinuing Mounjaro or Wegovy is common.
2️⃣ Biological factors, including hormone changes, play a significant role.
3️⃣ Lifestyle modifications, behavioral strategies, and alternative treatments can help sustain weight loss.
4️⃣ Long-term weight management requires ongoing commitment and support.
5️⃣ Consult your healthcare provider for personalized advice and alternative options.
When patients discontinue GLP-1 receptor agonists like Mounjaro and Wegovy, weight regain is frequently observed. This phenomenon has been well-documented in clinical trials and real-world studies.
The primary reason for weight regain lies in how GLP-1 agonists function. These medications work by:
*Modulating appetite-regulating hormones.
*Lowering the body’s weight set point.
*Enhancing satiety and reducing caloric intake.
When treatment stops, these hormonal changes often reverse. As a result, hunger increases, and the body’s natural weight regulation mechanisms resume, often leading to significant weight regain.
*In the STEP 1 trial, participants who stopped taking semaglutide regained approximately two-thirds of the weight they had lost within a year.
*The SURMOUNT-4 study revealed similar trends with Mounjaro, showing a 14% weight regain within a year of discontinuation.
*These studies highlight the chronic nature of obesity and the challenges of sustaining weight loss once pharmacological support is withdrawn.
For more insights on how GLP-1 agonists function, visit our Treatments page.
GLP-1 agonists significantly influence the brain’s appetite centers by mimicking the hormone glucagon-like peptide-1 (GLP-1). This helps reduce appetite and increase feelings of fullness. Discontinuing the medication means that these appetite-suppressing signals weaken, leading to increased food cravings.
Additionally, cardiometabolic improvements seen during treatment often revert, including:
*Elevated blood pressure.
*Increased glucose levels.
*Higher cholesterol markers.
Weight regain isn’t solely due to lifestyle lapses. The body’s biological drive to restore its previous weight can be powerful. Therefore, combining lifestyle changes with continued medical support is crucial for many patients.
Looking to switch your weight loss medication provider? Learn more at Switch Supplier.
*Combine cardio exercises with strength training.
*Aim for at least 150 minutes of moderate exercise per week.
*Consider activities you enjoy, like dancing, cycling, or swimming, to make exercise sustainable.
*Focus on portion control and avoid eating while distracted.
*Practice the 80/20 rule – eat healthy 80% of the time and allow treats in moderation.
*Keep a food journal to track eating patterns and identify triggers.
*Regular check-ins with your healthcare provider can help monitor weight changes.
*Consider alternative pharmacotherapy if weight regain becomes problematic.
*Personalized plans are essential – speak to your doctor about ongoing management.
To explore more ways to maintain your progress, visit our News & Insights page.
While weight regain after stopping Mounjaro or Wegovy is common, understanding the underlying reasons and implementing effective strategies can make a difference. Long-term success often hinges on a combination of lifestyle modifications, medical support, and continued monitoring. Stay proactive and seek guidance from healthcare professionals to navigate this transition successfully.
The body’s hormonal balance shifts back to its previous state, increasing hunger and reducing metabolic rate.
While challenging, adopting sustainable eating and exercise habits can help mitigate weight regain.
Yes, medications like metformin and bupropion may support continued weight management.
Clinical trials suggest that significant weight regain can occur within a year.
Consult your healthcare provider to discuss the best strategy for your specific situation.
For more personalized advice, visit our Get Started page.
https://pubmed.ncbi.nlm.nih.gov/35441470/
https://pmc.ncbi.nlm.nih.gov/articles/PMC11101251/
https://pmc.ncbi.nlm.nih.gov/articles/PMC11589535/
https://pmc.ncbi.nlm.nih.gov/articles/PMC9542252/
https://www.medicalnewstoday.com/articles/wegovy-weight-loss-four-years-study
https://easo.org/is-coming-off-semaglutide-slowly-the-key-to-preventing-weight-regain/
https://www.bbc.com/future/article/20240521-what-happens-when-you-stop-taking-ozempic
