Mounjaro vs. Wegovy: comparing two semaglutide-based options

💡Key takeaways 

1️⃣ Mounjaro and Wegovy are both injectable medications aimed at weight loss but have distinct mechanisms of action.

2️⃣ Mounjaro targets both GLP-1 and GIP receptors, offering broader metabolic benefits. Wegovy acts solely on the GLP-1 receptor, aiding weight loss by suppressing appetite.

3️⃣ Mounjaro shows higher efficacy in weight loss compared to Wegovy but may carry unique safety considerations.

4️⃣ Both options have similar gastrointestinal side effects, but their dosage and administration vary.

5️⃣ Consulting with a healthcare provider is essential to determine the most suitable option.

Understanding Mounjaro and Wegovy - the basics

When exploring weight loss injections, two names frequently emerge: Mounjaro and Wegovy. These medications have gained popularity due to their effectiveness in helping individuals with obesity or related health conditions achieve significant weight loss.

Both Mounjaro (tirzepatide) and Wegovy (semaglutide) belong to a class of medications known as GLP-1 receptor agonists. However, Mounjaro goes a step further by also targeting GIP receptors, which may contribute to its superior weight loss outcomes.

While both drugs work by suppressing appetite, slowing gastric emptying, and improving insulin sensitivity, Mounjaro’s dual-action approach means it may offer additional benefits for fat metabolism and blood sugar regulation. This makes it an appealing option, especially for individuals also managing type 2 diabetes.

For more information on our weight loss treatments, visit our Treatments page.

Which is more effective for weight loss? - an in-depth analysis

Efficacy:

Clinical trials demonstrate that Wegovy helps users lose approximately 15% of their body weight over 68 weeks with the maximum dosage of 2.4 mg per week. Meanwhile, Mounjaro has shown even greater efficacy, with weight loss ranging from 15% to 22.5%, depending on the dose.

In comparative studies, about 84% of patients taking Wegovy achieved at least a 5% weight loss, whereas Mounjaro’s highest dose saw 96% of participants hitting the same mark. This stark difference highlights Mounjaro’s potential for more substantial weight reduction, making it a strong contender for those aiming for significant change.

Side Effects:

Both medications share common gastrointestinal side effects, including:

*Nausea

*Vomiting

*Diarrhea

*Constipation

*Abdominal pain

However, there are some distinctions. Wegovy may also cause fatigue, headache, and dizziness, while Mounjaro has been linked to thyroid C-cell tumors in animal studies, though the relevance to humans remains uncertain.

To learn more about the available weight loss injections, check out our Medications and Pricing page.

Choosing the right option - practical tips for patients

When considering Mounjaro vs. Wegovy, several factors can influence your choice:

1. Personal Health Profile:

   • If you have type 2 diabetes, Mounjaro’s dual-action mechanism may offer better glycemic control. Wegovy may be preferable for those seeking straightforward GLP-1 receptor activation without the added GIP effect.
     
     

2. Tolerance to Side Effects:

   • Due to its dual mechanism, Mounjaro may result in more pronounced gastrointestinal symptoms. Wegovy’s side effect profile might be milder for some patients.
     
     

3. Accessibility and Cost:

   • Availability and insurance coverage may vary. Mounjaro is newer on the market, so checking with your healthcare provider and insurance is crucial.
     
     

4. Medical Guidance:

   • Always discuss your medical history with a healthcare professional before choosing either medication. If you are considering switching treatments, visit our Switch Supplier page.

For a comprehensive guide on getting started with your weight loss journey, visit our Get Started page.

Conclusion

Choosing between Mounjaro and Wegovy involves weighing the potential benefits against side effects and personal health factors. While Mounjaro may offer superior weight loss outcomes, Wegovy remains a reliable option, particularly for those prioritizing GLP-1-specific effects. Consulting a healthcare professional can ensure that you choose the right path for your weight loss goals.

Frequently Asked Questions

Which is better for weight loss, Mounjaro or Wegovy?

Mounjaro tends to show higher weight loss efficacy due to its dual-action on GLP-1 and GIP receptors, but individual results may vary.

Are the side effects of Mounjaro worse than those of Wegovy?

Both medications share similar gastrointestinal side effects, though Mounjaro may cause more pronounced symptoms due to its dual mechanism.

Can I switch from Wegovy to Mounjaro?

Yes, but it is essential to consult a healthcare professional to ensure safe transitioning and dosage management.

Is Mounjaro approved for weight loss in the UK?

Yes, Mounjaro is approved for weight loss in adults with obesity or overweight (BMI ≥27).

How do I get started with weight loss injections?

Visit our Thinking of Starting page for guidance on your first steps.

References

https://www.uchealth.org/today/what-is-mounjaro-and-how-does-it-work-for-weight-loss/

https://www.gov.uk/government/news/mhra-authorises-diabetes-drug-mounjaro-tirzepatide-for-weight-management-and-weight-loss

https://www.uchealth.org/today/wegovy-vs-ozempic-the-truth-about-new-weight-loss-drugs/

https://pmc.ncbi.nlm.nih.gov/articles/PMC8717485/

https://www.fda.gov/news-events/press-announcements/fda-approves-new-medication-chronic-weight-management