💡Key takeaways
1️⃣ Mounjaro and Wegovy are both GLP-1-based treatments, but they differ in mechanisms, dosing protocols, and efficacy.
2️⃣ Mounjaro combines dual action (GIP and GLP-1), while Wegovy targets GLP-1 receptors only.
3️⃣ Proper dose selection depends on factors like BMI, comorbidities, and tolerance.
4️⃣ Gradual dose escalation helps mitigate common side effects like nausea.
5️⃣ Consulting with a weight loss specialist ensures safe and effective treatment planning.
Navigating GLP-1 dosing: the basics you need to know
When it comes to selecting the right dose of Mounjaro or Wegovy, understanding how each medication works is essential. Both Mounjaro and Wegovy are classified as GLP-1 receptor agonists, but Mounjaro also includes GIP agonism, offering a dual-hormone approach. This combination can enhance metabolic effects, potentially leading to more significant weight loss in some individuals.
Understanding the Mechanisms:
-
Wegovy (Semaglutide): Primarily a GLP-1 receptor agonist, stimulating insulin secretion and slowing gastric emptying, leading to reduced appetite and improved glycemic control.
-
-
Mounjaro (Tirzepatide): Combines GLP-1 and GIP receptor agonism, enhancing insulin secretion and promoting greater weight loss by targeting dual metabolic pathways.
For more insights on our treatments, visit our Treatments page.
Mounjaro vs. Wegovy: choosing the right dose for optimal results
Dose Escalation and Maintenance:
One of the most critical aspects of using GLP-1 medications safely and effectively is the gradual dose escalation. Both Mounjaro and Wegovy require a titration period to reduce gastrointestinal side effects.
Wegovy Dosing Protocol:
Starting Dose: 0.25 mg once weekly for the first four weeks.
Escalation: Gradually increase every four weeks (0.5 mg → 1 mg → 1.7 mg → 2.4 mg).
Maintenance: 2.4 mg per week. If intolerable, reduce to 1.7 mg.
Mounjaro Dosing Protocol:
Starting Dose: 2.5 mg once weekly for four weeks.
Escalation: Increase by 2.5 mg every four weeks, up to a maximum of 15 mg weekly.
Maintenance: Typically 10–15 mg, depending on individual tolerance.
Choosing the Optimal Dose:

Patient Profile: Consider factors like BMI, comorbid conditions (e.g., diabetes), and weight loss goals.
Tolerance Levels: Some patients may need to pause dose escalation if gastrointestinal symptoms become severe.
Metabolic Needs: Mounjaro may be more suitable for those with insulin resistance due to its dual action.
For more details on the pricing of these medications, visit our Medications and Pricing page.
Practical strategies for effective dose management

Listen to Your Body:
Gradual dose escalation is key to minimizing side effects. Start slow and increase cautiously, as your healthcare provider advises.
Monitor for Side Effects:
Common side effects include nausea, vomiting, and diarrhea. Report any severe symptoms to your healthcare professional promptly.
Stay Consistent:
Take your medication on the same day each week to maintain stable blood levels. Use a reminder or calendar to help with consistency.
Lifestyle Integration:
Combining GLP-1 therapy with lifestyle changes—like a balanced diet and regular exercise—can enhance results. Learn more about starting your weight loss journey with us on our Thinking of Starting? page.
Talk to Your Doctor:
If you’re considering switching from one GLP-1 medication to another, consult your healthcare provider to ensure a smooth transition. Find out more about switching providers on our Switch Supplier page.
Conclusion
Choosing between Mounjaro and Wegovy—and determining the right dose—requires a personalized approach. By understanding each medication’s mechanisms and following a structured dosing protocol, you can optimize your weight loss outcomes while minimizing potential side effects. Always consult a healthcare provider for tailored guidance.
For any further questions, reach out to us via our Contact Us page.
Frequently Asked Questions
Can I take Mounjaro and Wegovy together?
No, combining these medications is not recommended due to overlapping mechanisms and increased risk of side effects.
How long does it take to see results?
Results vary, but noticeable weight loss typically occurs after 8–12 weeks when the target dose is reached.
What should I do if I miss a dose?
Take the missed dose as soon as possible if within three days. Otherwise, skip it and continue with your next scheduled dose.
Can I switch from Wegovy to Mounjaro?
Yes, but it should be done under medical supervision to adjust dosing and manage potential side effects.
Are these medications available on the NHS?
Wegovy is more commonly available on the NHS for specific BMI criteria. Mounjaro is primarily used for diabetes management but may expand for weight loss in the future.
References
https://pmc.ncbi.nlm.nih.gov/articles/PMC7566932/
https://pubmed.ncbi.nlm.nih.gov/22041461/
https://diabetesjournals.org/care/article/47/11/1873/156807/Efficacy-and-Safety-of-GLP-1-Medicines-for-Type-2
https://www.accessdata.fda.gov/drugsatfda_docs/label/2022/215256s005lbl.pdf
https://pmc.ncbi.nlm.nih.gov/articles/PMC10533252/
https://www.accessdata.fda.gov/drugsatfda_docs/label/2022/215866s000lbl.pdf
https://www.gov.uk/government/news/mhra-authorises-diabetes-drug-mounjaro-tirzepatide-for-weight-management-and-weight-loss
https://pmc.ncbi.nlm.nih.gov/articles/PMC7900946/
https://jme.bmj.com/content/early/2025/03/20/jme-2024-110374
https://researchbriefings.files.parliament.uk/documents/CBP-10171/CBP-10171.pdf
https://www.jmcp.org/doi/10.18553/jmcp.2024.23332
https://www.gov.uk/government/news/mhra-reminds-healthcare-professionals-to-advise-patients-of-the-side-effects-of-glp-1-agonists-and-to-report-misuse
https://www.ncbi.nlm.nih.gov/books/NBK551568/
https://diabetesjournals.org/clinical/article/41/3/467/148676/Special-Report-Potential-Strategies-for-Addressing
https://commonslibrary.parliament.uk/research-briefings/cbp-10171/
https://www.bmj.com/content/384/bmj-2023-076410
https://www.diabetes.org.uk/about-us/news-and-views/our-response-serious-supply-issues-drugs-people-living-type-2-diabetes
https://medlineplus.gov/druginfo/meds/a618008.html
https://medlineplus.gov/druginfo/meds/a622044.html
https://www.who.int/news/item/20-06-2024-who-issues-warning-on-falsified-medicines-used-for-diabetes-treatment-and-weight-loss
https://pubmed.ncbi.nlm.nih.gov/19937677/